When people use ad blockers, there is still a way to get your point across, show a scaled down, minimalistic ad in an non-obnoxious way, that usually won't have people complaining about it.
Have you seen what happens when you visit sitepoint.com with an ad blocker turned on? If you visit any of their article pages, you'll see something like this, in place of the normal ad banner:Forbes forces users to disable ad blockers, promptly serves malware.
It's just text. No links, images, animations, videos, audio, flash, corporate logos, or anything else. Just text. This is what they show instead of a "please turn off your ad blocker" message.
If more companies would take this approach, then adblock users, site owners, and advertisers could co-exist peacefully. Of course this would require advertisers to deal with sites directly, rather than through advertising networks, which would probably put most of the nastiest advertisers out of business.
But that would be a win-win situation, if you ask me.