First thing I'd do is switch to Firefox, when having that many tabs open in a browser, Chrome isn't really good at that, consuming lots of memory and CPU when the tab-count goes up. I'm running one of my Firefox instances with 300 tabs, without trouble, but I do turn off that computer at the end of my workday.
I try to never touch the pagefile size, at least not since the Windows 2000 days, back in the Windows NT 4.0 days it seemed to make sense to tune it, but after that it usually got worst whatever way I tuned it away from the Windows optimal/automatic settings. Theoretically, Windows running on a 16 GB system should be able to do without any pagefile, but I've found that Windows can get really instable that way, so that's IMHO a good reason not to touch it.