I do this for my media machine, which is just a quad core running Win7, but I don't use it very much as a "normal" computer. I have a wireless keyboard and mouse for it, so it certainly can (and sometimes is) used that way, but depending on the size of your display, wireless may be a necessity to sit far enough back from it to see everything. The other important bit is to find the native resolution of the display and then set your graphics card for that. With any luck your system will detect it, but you may have to download a driver for the display, or look up the specs and set it manually.
- Oshyan