Out of curiosity, have you changed the label for the partition recently (I recall from other threads that you wanted to get rid of a partition). Anyway, the reason I ask is that even if you request that your partition management software redirect shortcuts and so on if it is re-assigning partition labels, it ofen misses key assignments. This happened to me a year ago when reassigning my data partition's label. I'd check a random shortcut's path to make sure it's pointing to e:\... and not f:\... or g:\...
Just a shot in the dark. Good luck!