Most of the my apps are made in Autohotkey and few in AutoIt.
I look for the feature of the app which I am going to develop and take up which I find "easier" for me. Nothing personal, just similar done previously or have a similar sample etc. makes my preference.
If you feel at home in AutoIt, it is OK. If you need to code some feature which you can not find in AutoIt, then you may have to look around.