This could be really helpful for me, so I'm glad you've responded, Carol - this has been driving me a little nutty for awhile. Here's my experience: when I run Hostsman, it's always greyed-out, meaning that some other program has control of the Hosts file (I think that's how they put it in the Hostsman manual); so I open Process Explorer and search on 'hosts', and it tells me that three poscesses are connected to 'hosts': gss.exe (twice, for some reason), and hm.exe (which are Ghost and Hostsman, respectively). Now you can't shut down GSS very easily, because it's running at such a low level. I have tried to used Startup Delayer to delay GSS running, so that Hostsman could get priority on the Hosts file, but I expect there's a pretty fundamental flaw in my thinking... But no, the file (at C:\WINDOWS\SYSTEM32\DRIVERS\ETC) is not marked as read-only or hidden. Would love to find a solution to this, because I quite often find innocuous sites blocked and want to be able to edit my Hosts when I need to.