As far as I know, the answer is no. Unless you wanted to open up your mouse and change the wiring around on the inside. 
Actually, I don't know why people just don't design left handed mice/mouses/mieces that way. I'm brilliant! 
-Deozaan
if I plug in left AND right-handed mice, both do work as would be expected
LEFT RIGHT
context|click click|context
my problem is the lefthanded mouse - I like the design, think I'll stick with it, but find the top(right)button too short & therefore harder to use so I wanted to change it's behaviour to opposite of default.
Unfortunately, as said above that's changes the right mouse too
I wish that it was possible to have double independant mouse ipointers on the screen as well
Then one could use 2 mouse simultaneously!-kartal
did you see the thread linked to end of first post (no solutions though)
I have used two mice before but they were both righthanders
I was happy enough using the righthand settings with my left hand - in fact I've gotten very used to that...
anyone got any ideas there?-tomos
With dexterity such as that I think you should have entered the Olympic Mousing event. 
-cranioscopical
a bit like Jimi Hendrix learning the guitar by turning it upsidedown so he could play it left handed (I wish) - when I tried to change my ambidextrous logitech mouse to lefthanded settings I just couldnt adjust to it - that's probably part of my problem now...
I know that the cd that came with my keyboard/mouse combo (that logitech claims doesn't exist) allows me to configure the mice separately I believe. it would detect the mouse plugged into the ps/2 port, and when I plugged in my wired usb mouse it detected it and asked if I wanted to configure it, so I am guessing that each one would have different button configs. The software that came with my combo is itouch (keyboard media keys), and mouseware.
-nite_monkey
thanks nitemonkey, I have a couple of PS2 adapters in a drawer here somewhere so will try that, also
I've downloaded mouseware from cnet, my logitech mouse came with software called setpoint, could try that too
