this is the way (flaw) of nod32, an otherwise great antivirus.
there are actually a few rare apps that become completely unusable if nod32 isnt configured to ignore them (oxford dictionary).
to see that this is nod32 at fault, go to nod32 amon settings, and in options UNCHECK "runtime packers","Self-extracting archives","Advanced Heuristics".
actually i think its probably just the first 2 that matter, but then i disable heuristics anyway since nod32 can false positive on some apps with that setting.
after you turn those off youll see the setup programs runs at jet airplane speed
