This guy is on their runners up list for ergonomic mice, and will be arriving at my home in a few days. (a Giftmas gift from a very generous person!)
I am really looking forward to it, as I am developing a very sore spot on my wrist where it rubs against my desk. (had to toss my mousepad with the wrist rest about a year ago because it was causing serious skin damage on same spot.)
Evoluent VerticalMouse 2
I'll post my own review on it in February, after I have had a chance to give it a good try.