The Master Genealogist
is supposed to be one of the best, most powerful, feature rich ones available.
It is intended for professionals and those that are obsessed with recording every last detail, right down to DNA logs for DNA test results.
Supports GEDCOM and importing from over 20+ other applications.
It is even capable of publishing a book complete with contents, footnotes, multiple indexes and bibliography.
There are also a number of companion products
, in case the ton of features they give you isn't enough.
They have a downloadable guided tour
that will take you through the basics.
Cons: It has a higher price tag ($59.00 download/$79.95 on disk - gold version) and because it is so feature loaded, it has a steeper learning curve.