well, content searching would be nice for my ebook collection, but other than that I often remember part of filename, and have an easier time searching that rather than indexing (I often search for a downloaded .zip/.rar/.tgz or .exe, a bit hard to index those - unless you index the content of the packed files, which would be quite a task
). I wouldn't mind playing a bit with content indexing, but haven't find an app that I liked (tried Archivarius 3000, but it took forever and said it would use 100+ GB for the index, no-go). Anything with a web-based interface is a no-go.
Things seem pretty fine on XP64 for me, no hardware/driver problems (but of course I don't really use scanners or printers, those seem to have been the biggest offenders). The apps I've installed so far haven't been a problem either.
Games could be problematic, but nocd cracks tend to fix that situation (yeah, too bad you have to turn to illegal sources to be able to play legit games, but hey - it's a win/win situation wrt. startup and running speed as well).