After some unsuccessful attempts via genisoimage and trying a (successful but rather lengthy) work-around via UDF, re-encountered xorriso:
Xorriso creates, loads, manipulates, and writes ISO 9660 filesystem images with Rock Ridge extensions. Files can be copied in and out. Optionally it supports hard links, ACLs, xattr, and MD5 checksums. The session results get written to optical media or to filesystem objects.
Burned a BD-RE with an ISO containing a file larger than 4GB. Apparently some OSes may not handle the result, but FWIW...