I use True Launch Bar and MacroExpress Pro in launching most of my frequent use programs. Both handle hotkeys combination [Win] + [Ctrt] + <key> very well.
[Win] + [Enter]/[SpaceBar] for True Launchbar
[Win] + [Ctrt] + E for IE
[Win] + [Ctrt] + G for Genie Backup Manager
[Win] + [Ctrt] + H for HyperSnap
[Win] + [Ctrt] + O for Opera
[Win] + [Ctrt] + S for SyncBack SE
[Win] + [Ctrt] + V for Visual FoxPro
[Alt] + [num INS] for Comfort Clipboard
and many more ... (I hate MS for seizing my [Win] + [Ctrt] + P keys)
The above is typed from my memory, I suppose I am born with special memory to quickly and easily remember many hot keys or shortcut keys
... come to think about it, I also remember and use a different set of hotkeys inside most of my frequent use utilities like EmEditor, Total Commander etc.
I have 2 very frequent use programs launched by mouse-click via MS Mouse IPOINT utility. I launch Total Commander with MS Mouse's big side button and middle button is reserved for Listary.
For less frequent use program I find them (by typing accelerate keys) from the True Launch Bar menu.
In brief, I hardly click to launch a program and I usually dislike programs that are not keyboard friendly.