The music from Final Fantasy X (a game) also helps the emotional impact.
It is quite interesting in a game like that, where time passes in the game much like in the real world. Seasons change, people (animals) move in and out of the village. And they remember your interactions with them.
If you don't play for a while, weeds sprout all over town, the animals wonder where you went or if you forgot about them, cockroaches infest your house, etc.
The interesting thing about this story is that it isn't really the game that affected the emotion. The game was just the vessel by which the mother showed love to her children, and the means by which the child realized that love in such a profound way.