It may or may not be possible for folders, it depends how the FS stores the data.
Another way you can acheive a similar idea is to have a Desktop.ini file in each folder.
Common folders like "My Pictures" have these set up by default and is the reason such folders appear with icons. To see the Desktop.ini file you have to enable viewing hidden and system files in the Folder Options.
There are a number of commands you can include in the desktop.ini file which will allow you to add icons and also tooltips when the mouse hvers over the folder (which could effectively be a comment). Try hovering over My Documents and a comment/tool tip will pop up.
To see how it is dones have a look at some of the system desktop.ini files or check out this link for details:
http://msdn.microsoft.com...sics_extending/custom.asp