Interesting presentation, and memories! 
http://www.gamasutra.com/view/news/275482/From_PS4_to_144_MB_floppy_Porting_Retro_City_Rampage_to_MSDOS.php
The other video/talks referenced in the video are also interesting.

Quote
At GDC 2016, Provinciano elaborated on exactly how he did it, and in the process shed light on how he reduced memory usage down to 4MB, increased performance to run on a 486 PC, reduced disk space to fit on a single 1.44MB floppy, and finally ported the game to MS-DOS itself.
http://www.gamasutra.com/view/news/275482/From_PS4_to_144_MB_floppy_Porting_Retro_City_Rampage_to_MSDOS.php
The other video/talks referenced in the video are also interesting.


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