What about the standard Win10 toolbars?
Right-click on the taskbar, open Toolbars and select Desktop (like I did), or add a new toolbar, pointing to a folder where you create links to your files/applications as desired. Multiple toolbars can be defined.



Example of my (partial) Desktop toolbar:



The advantage of TrueLaunchBar (shareware) is that the menu pops out on mouse-hover, where the Windows toolbars need a mouse-click to open.

You should be able to drag the right side of the setting panel to the left with the mouse:



(The drag handle moved a bit to the right when taking the screenshot...)
Just move the mouse over the separating line in the middle until it changes into a left-right drag handle, then click and drag to the left, (that might take some precision-mousing on your high-res monitor though :tellme:)

Have you tried playing with the Compatibility/High DPI settings per application? It's in the <Right-Click-icon>/Properties pages of the application.

And some applications support Ctrl-scroll-wheel-scrolling for scaling only their window/font.