The only trouble I've had is the occasional file-lock.  If I didn't have Unlocker installed, I'd probably be more upset about that.

But I've excluded huge swatches of my harddrive from Copernic's questing fingers of doom, particularly my sourcecode folders.  That seems to have helped tremendously.

The v3 crippleware is fine for my needs.  Since I added the 2TB external RAID and moved all the server-based files to local drives, I no longer need to index network shares.

So, for me, it's a decent solution.  *shrug*

I just updated my vote, since I now use Copernic.  Seems to be the best jack-of-all-trades compromise between performance, beauty, ease of use, and stability.

NOD32 continues to impress, because of its performance and lack of paranoia.

I use AVG 8 on my test machines, and am constantly pelted with false positives.  This can be more dangerous than actual infection; the Cry Wolf syndrome.  On the other hand, AVG detects real threats as soon as the file exists -- NOD32 seems to require the file be executed before swinging into action.

This can be a catastrophic failure, since some of the newer malware fires off zillions of threads to attack your system, and NOD32 gets tangled up trying to stop them all.  In these circumstances, I simply ignore NOD32's "repair" option and go straight to restoration of a backup.  The end result is the same -- PC not infected by nasty trojan or whatever -- but AVG would have prevented the infection to begin with.

I've encountered people who run multiple virus scanners concurrently, and always thought them a bit paranoid.  Am now questioning this assumption.

Opinions?