H-Menu might do what you want. I haven't tried it myself yet but it looks highly configurable. I downloaded H-Menu 6.0 from A+ Freeware.

Here's a description from Virtualplastic: "H-Menu is a fully configurable launcher, yet it remains invisible until activated with the mouse. (...) Animated Toolbars appear on contact with the screen’s edge, up to two per side. H-Menu also supports the use of Cascading Menus and Multimedia capabilities. (...) The number of Buttons per Bar and their size can be configured and you can use your own bitmaps as backgrounds. Also you can create many sets of Buttonbars under different user names and groups, then navigate between them with links on each of the Buttonbar groups." Loads of options :)"

1. MSHelpWiki see Available Tools and Software Reviews.

2. CHMTools

3. Check out Microsoft's Office Resource Kit (Browse to Creating Custom Help for info).