Simple, clean and with everything I don't care about hidden away.  At one point I tried to fight the silly ms naming convention, but more recently, I decided to go with it for consistency (rather than fight it) and it has made my life easier.  Accept the convention and things get less painful.  (Microsoft did away with the convention in Vista, go them).

-My Documents
+---My Connections
|   +---Home
|   |   +---Shortcut to some connection to home (vpn / putty / etc)
|   |   +---Shortcut to some connection to home (vpn / putty / etc)
|   +---Work
|   |   +---Shortcut to some connection to work (vpn / putty / etc)
|   |   +---Shortcut to some connection to work (vpn / putty / etc)
|   \---Personal Servers
+---My Downloads
|   +---Stuff
|   |   +---Random
|   \---Things
+---My Music
|   +---iTunes
|   |   +---iTunes controlled structure
|   +---Raw
|   |   +---raw FLAC files
+---My Pictures
|   +---Friends
|   \---Family
+---My Projects
|   +---Company A
|   |   +---Project 1
|   |   |   +---Trunk 1
|   |   \---Project 2
|   +---Company B
|   |   +---Project 1
|   |   |   +---Trunk 1
|   |   \---Project 2
|   +---Personal
|   |   +---Project 1
|   |   |   +---Trunk 1
|   |   +---Project 2
|   +---Shared
|   |   +---Project 1
|   |   |   +---Trunk 1
|   |   \---Project 2
\---My Texts
    \---Company
        +---Ideas
        |   +---Idea 1
        |   \---Idea 2
        +---Networking
        \---Receipts
    \---Personal
        +---Ideas
        |   +---Idea 1
        |   \---Idea 2
        +---Networking
        \---Receipts