HIPS programs you're talking about... I don't know if they would go so down in the stack. They're quite capable of detecting software trying to launch other apps, code injection and such, but with rootkits it would be another story. Who knows? If Gizmo says they would prevent them, then take his word for granted. The guy lives of that.
Besides, actual rootkits are much more sophisticated than this. I think Altiris would be something like in the league of Norton's Antivirus Recycle Bin, which intercepted the files going to the bin, and rerouted them to his own directory.
Sysinternals tool is quite capable, but in the end, you're alone, unless you post your log in their forums. It's not easy to understand, and you've got to remove possible rootkits by yourself. I wouldn't count too much on Resplendece tool as well, this is not their field of action. F-Secure on the other hand, was (I think) one of the first scanners, but according to an article f0dder linked:
btw it's not just a coincidence that the Ad-Aware engine uses another PR crap firm F-Secure in their products for fighting with spyware. Nice simbiotic
... who knows, it could be true, or it could be some guy crying because he can't bypass F-Secure detection algorithms. Another search showed me that rootkit authors are in a rat race with security software writers, as always. WinHex could be also a helpful tool, but it's also difficult to use.
Enough senseless chit-chat. Where is f0dder?