In Vista x64, the GUI and tray appeared to be running 'fine', however it never would tame anything... its core process lowering function would never kick in. Even at constant 100% cpu usage. First I changed the Shortcut properties in Startup:Process Tamer to run as Adminstrator .
Then I realized the "CPU Usage Measurement Smoothing Over Time" slider bar was set way to the right (like at 75% of 100), which meant it would take a LOOONG time to react and ever kick in, so I slid it back towards the left about 15% of 100.
Not sure if this is a default setting under Vista, but if so, it needs to be checked why it is set wrong by default, and set to a much lower value like during other (XP) installs.
I thought perhaps maybe it may have been an old preference file that was left behind from a previous install, but I doubt it, because if so I would of had the "Run High Priority" checkbox set, "Run at Windows Startup" set, etc. which were not... not to mention I wouldn't have put that slider bar so far to the right because I understand what it does. So if during an uninstall Process Tamer deletes the preference file, and recreates it during a new install, this needs to be checked under Vista x64 and figured out what weird little bug makes it set the Smoothing Window Slider bar so far to the right.
This is probably some weird little niggling bug, that crops up during a Vista install, or a Vista x64 install.