> Although for me uBlock Origin was not a viable alternative. The cure was worse than the disease. Enough sites went weird with it running that I just got rid of it.
(Wait.. the below is for uMatrix!)
I think the trick, especially on youtube sites which should have a global allow somehow, is to quickly hit the block and either make one or two reds green (frame and all) which still leaves nonsense things like google-analytics blocked. Or simply disable (top, toward the left.) The point is that if you have 15 or 20 websites open that are ok, they are far less likely to be scripting away to plunge your firefox into darkeness. A reasonable trade-off.
If I remember, I dumped uBlock Origin also.