Well...I'm sure you could modify (and somebody probably already has) the keybindings. But why bother? If it's that big an improvement, you're probably better off using the defaults. Especially if you don't have the luxury of working exclusively on your own boxes.
That's the real reason I stopped using Dvorak keyboards a long time ago despite the fact I greatly preferred them. Once I left home it was a major pain. After a while it was just easier to use what everybody else was using for something as basic as a keyboard.
If TMUX really is that great, I'll probably switch and sit down to learn yet another set of quirks.