I hope people will come up with variants or even completely new games based on the different cards and share them.
In order of ease of doing the rules:
Reversing the similarity to regular cards, means all those rough card-like games would work, though they would make somewhat less sense. Crazy 8's, get two packs and do Go Fish, Old Maid, etc. All the solitaires would work too.
Going farther afield, this is 3rd cousins to the Magic the Gathering style of "My creature vs your creature with artifacts and addons and threats".
Way left field might be something New Age.
Any of that sound fun? : )