Well, you've shown me yours, so I'd better show you mine:Show us your desktop
I have 3 screens in a row, and I use them in a very strict way.
Left Monitor: this is my "info screen". At a glance I have time, date, system status, etc. I also keep my browsers, todo list, and scratchpad over here.
Middle Monitor: this is where I have my IDEs, CRM, email etc. to hand.
Right Monitor: this is the DOpus, SQL and message screen. Calls, skypes etc. appear here, and this is where all the filing, copying, uploading etc. goes on. And random deletions from important client databases.
I should make a special mention of a couple of things that didn't show up on the screen: FARR of course, and skwire's marvellous DropMove thingy.