I came across this comparison chart some time ago. It's a little dated. But it does give a flavor of what's available.http://www.wilsonweb...sktop_comparison.htm
I doubt it's comprehensive and the scenario may have changed significantly since then.
One example is I think the chap who was marketing Mailloop, Cory Rudyl, apparently died in a car accident and someone else has now taken over. How does that change the equation ? Well, I don't know.
I came across and tested a List Management software quite a while back out of interest and it looked like it was one of those more capable I have come across and fiddled around with.
I cannot remember if it has a sending module. But it was very good at managing list if my memory does not fail me. Back then it was version 1.2. But it's Listmotor 2.0 now. But yikes, it's $149. But if you have big and dynamic list, and do it regularly, it may be worth it and it would keep the list neat and tidy for you.http://www.listmotor.biz/index.htm
But I'm no expert on such programs and all the inter-connected intricacies so this is just my 2 cents worth.