I've only gotten round to trying that today - I had to give my left arm a rest so was just using right mouse for the last week (I'm left-handed)
when I click Win+S first a small "0" in a box shows just SE of cursor,
when I click again, a "1" shows again just below/right of cursor
These dont go away, I mean there's always one of them there ..
But a bigger problem is that on second click the mouse settings box opens - it opens the logitech tab with a wizard to help you asking which side of keyboard the mouse is etc.
I will try uninstalling the logitech soft - only installed it to see could I get around this problem some way - and see if that helps
Was thinking maybe it using this hotkey too but can find no indication othat - but you never can tell !