I have switched recently to Vista (32 and 64) and have following issue with Clipboard H&S (newest version). The configuration is just not being memorized/saved. While changing (manually started the tool), everything looks good, but once closed, nothing was saved. No errors.
I think, this might be a security issue by Vista, which just blocks Clipboard to store the data - anyway, where does clipboard store the config (registry or file), maybe it's just a small tweak to enable this.