Wow, GridMove is just what I've been searching for - I downloaded as soon as I found it and setup my grids within minutes.  I'm a visual person, so I "forget" what else I have going on so I like to have everything open and clickable without ALT+TAB or taskbar.

Sharing my setup which is pretty simple (6 grids) over two big monitors.  Monitor 1 is workspace where I have three overlapping windows so I can work on script or document in one while browser and e-mail visible "behind" (at least I can see if email comes in and my to do list).  Monitor 2 is big workspace with a "sidebar" where I can stick Skype and IM and see them all without juggling windows.